You can get to us from either the Florida Turnpike to Route 1, or directly from Route 1.
Follow Route 1 South off the mainland into the Florida Keys (yup ... 1 way in and 1 way out!) Enjoy your scenic ride through the Keys, to approximately MM 33. Turn left at the Big Pine Fishing Lodge (this is important, there's no other landmark), onto Long Beach Drive. Go 2 miles on Long Beach (obey speed limits, endangered Key Deer are all through the area, and will cross right out in front of you ... as might an errant turtle or 2). Turn left into Deer Run. Park in designated area.
1997 Long Beach Road
Big Pine Key, FL 33043